Keto 101

WELCOME TO TRURISE KETO 101. THIS IS WHERE YOU LEARN ABOUT OUR EXOGENOUS KETONES.



At TruRise, we love helping people rise to their true potential. In order to elevate your life with us, it will benefit you to know how your amazing body is designed to work with our cutting-edge products to help you live at a higher level.

 

WHAT ARE TRURISE KETOSURGE EXOGENOUS KETONE DIETARY SUPPLEMENTS?

TruRise KetoSurge products are scientifically formulated using a safe, potent and effective form of exogenous ketones (Beta-Hydroxybutyrate “BHB”), vitamins, minerals, micronutrients, electrolytes, fatty acids, probiotics, herbal extracts and digestive enzymes. These supplements were designed to help you reach your wellness goals while eating a low carbohydrate, high fat diet. When eating a low carbohydrate diet, the liver converts fats into ketones, which serve as an alternative energy source for the brain, heart and muscles. When your lifestyle includes the amazing KetoSurge exogenous ketone products, you are ingesting essential vitamins, minerals, micronutrients, electrolytes, and ketone bodies that give athletes, on-the-go moms and dads, and busy professionals more energy, better performance, and improved focus.†

Taking TruRise KetoSurge products while maintaining a low carbohydrate, high fat diet will effectively lift your energy levels, as fat has more than double the energy per gram than sugar/carbs. By placing your body into a ketosis state, you will likely notice a lift in energy levels and a reduction of sugar cravings and appetite, which in turn will help you lose your stubborn fat.†


HOW CAN THE TRURISE KETOSURGE PRODUCT LINE HELP YOU REACH YOUR HEALTH AND WELLNESS GOALS?

The TruRise KetoSurge product line can dramatically shorten the time it takes to achieve a ketogenic state, especially TruRise KetoSurge Fuel. These products allow for more flexible dietary freedom. For example, without the TruRise KetoSurge Fuel, you would have to eat a higher fat-to-carb ratio to visibly see the desired results, which some people often find restricting and difficult. But with TruRise KetoSurge Fuel, you can enjoy a less restrictive diet to see improvement in your wellness program.



INTEREST IN THE LOW CARB/HIGH FAT KETOGENIC LIFESTYLE IS RISING.
LEARN MORE HERE!

Interest in the ketogenic diet is growing every day. Below are some answers to common questions about the unique ketone body, Beta-Hydroxybutyrate, and how it is used in TruRise exogenous ketone dietary supplements.

1. WHAT IS BHB?

Beta-Hydroxybutyrate (BHB) is a ketone body produced when free fatty acids are broken down in the liver. The other two types of ketone bodies are acetoacetate (AcAc) and acetone. Ketones provide pure energy to fuel the human brain and other tissues. The liver is always producing ketones to some small degree, and they are always present in the bloodstream. Under normal dietary conditions, ketones are too low to be of any significance. A very low carbohydrate diet, a ketogenic diet and exogenous ketone supplements like TruRise KetoSurge line of products will help you increase the amount of ketones in your body.

2. WHAT IS A KETONE BODY?

When eating a low carbohydrate diet, the liver converts fatty acids to ketones, which serve as an alternative to glucose for energy for the brain, heart and muscles. Ketone bodies (Ketones) are energy sources that are produced and burned under special metabolic conditions such as starvation and high fat (ketogenic) diets. Ketones are a super fuel that can be efficiently used by the muscles and the brain, which generates more energy (ATP) per unit of oxygen consumed than carbohydrates, protein, or fat.

3. WHY DO WE MAKE KETONES?

Our brain can only function with glucose and ketones. Since we can’t store more than about 24 hours worth of glucose, we would be in a hypoglycemia state if we were ever forced to fast for more than 24 hours. Fortunately, our liver can take fat and select amino acids (the building blocks of protein) and turn them into ketones, first and foremost to feed our brains. Hence, our body’s ability to produce ketones is required for our basic survival.

4. WHAT IS KETOSIS?

Ketosis is a metabolic state in which the liver produces small organic molecules called ketone bodies. The term “ketone bodies” refers to 3 very specific molecules: acetone, acetoacetone (or acetoacetic acid), and beta-hydroxybutyrate (or beta-hydroxybutyric acid), shown below.



Steps 1, 2 and 3
 

5. HOW DOES BHB WORK?

Beta-Hydroxybutyrate is a ketone body providing a direct energy source to the brain and muscles. You do not have to be in a full ketogenic state to benefit from BHB. Even those who follow a low carbohydrate diet can experience the benefits of higher energy and better performance.

6. HOW CAN I USE BHB?

BHB is most often used for energy, fat loss, endurance, and cognitive formulas or as a “bridge” to nutritional ketosis. During the period of time when your body is learning to switch from burning glucose to burning ketones, you can experience a lack of energy. Exogenous ketones can help “fuel” you during that transition period. Because BHB is used in higher doses, it is typically used in powder formulas such as TruRise KetoSurge Fuel.

7. DOES BHB WORK, EVEN IF I EAT SOME AMOUNT OF CARBS?

Studies suggest that BHB can work even when outside of nutritional ketosis. Please see several referenced studies below for detailed information. Also, ketones can help spare glycogen for those exercising for longer periods of time. Despite ingesting carbs, ketones can still enter the cycle generating ATP.

8. WHY IS BHB SUPPLIED IN THE FORM OF CALCIUM, MAGNESIUM AND SODIUM BHB?

BHB is not stable in isolation, so it is “bound” to these minerals for stability. Additionally, the minerals serve a dual function as those in nutritional ketosis often need more calcium and sodium.

9. WILL THE SODIUM IN SODIUM BHB LEAD TO HIGH BLOOD PRESSURE?

Some studies suggest that sodium chloride (table salt) leads to high blood pressure, but not all organic sodium salts do. Please see the following study: http://www.ncbi.nlm.nih.gov/pubmed/15193367. Ask your doctor and please note that these statements have not been evaluated by the Food and Drug Administration. TruRise products are not intended to diagnose, treat, cure or prevent any disease. More study is required to have a definitive answer.

10. IS BHB JUST FOR ATHLETES?

No! Anyone looking to maximize their wellness goals on a low-carbohydrate or ketogenic lifestyle, and feel more energetic throughout their day will love BHB. Busy professionals, on-the-go moms and dads, and college students looking for extra hours in the day may benefit from BHB.

 

BUSY PROFESSIONALS, ON-THE-GO MOMS AND DADS, AND COLLEGE STUDENTS LOOKING FOR EXTRA HOURS IN THE DAY MAY BENEFIT FROM TRURISE KETOSURGE EXOGENOUS KETONE PRODUCTS!

 

11. CAN VEGETARIANS OR VEGANS FOLLOW A KETOGENIC DIET?

Yes! While some may find it difficult, this can still be done.

12. SHOULD I TAKE FIBER SUPPLEMENTS?

It is possible to get recommended daily fiber intake through vegetables; however, taking fiber supplements may help some individuals who cannot get their dietary intake of fiber from their regular daily meals.

13. CAN I HAVE COFFEE?

Yes! You may consider adding healthy fats like MCTs to your coffee.

14. WHAT ARE EXOGENOUS KETONES?

Exogenous ketones are ketone supplements that are ingested to enhance plasma ketone levels and act as a metabolic fuel source for the body.

15. HOW DO I TEST MY KETONES?

Ketone bodies can be checked via blood ketone meters, ketone urine strips, or breath analysis.

16. HOW LONG DOES IT TAKE TO GET INTO KETOSIS WHEN I USE TRURISE KETOSURGE FUEL?

Ketone levels can increase high enough to consider being in ketosis within days of severe carbohydrate restriction or fasting. True adaptation takes longer. However, with TruRise KetoSurge Fuel, you can be in ketosis within hours.

17. WHAT IS DIABETIC KETOACIDOSIS?

When a diabetic (usually a Type I diabetic, but sometimes this occurs in very-late stage, insulin-dependent, Type II diabetics) fails to receive enough insulin, they go into a state of starvation. While they may have all the glucose in the world in their bloodstream, they can"t get any into their cells without insulin, effectively going into starvation. When this happens, the body does what it would do in anyone—it starts to make ketones out of fat and proteins. In this case, the diabetic person can’t produce any insulin, so there is no feedback loop and they continue to produce more and more ketones without stopping. By the time ketone levels (specifically, beta-hydroxybutyrate) reach 15 to 25nM, the resulting pH imbalance leads to profound metabolic derangement and the person becomes critically ill.

The state of metabolic derangement is not actually possible in a person who can produce insulin, even in small amounts. The reason is that a feedback loop prevents the ketone level from getting high enough to cause the change in pH that leads to ketoacidosis. A person who is said to be “Keto-adapted,” or in a state of nutritional ketosis, generally has beta-hydroxybutyrate levels between approximately 0.5 and 3.0 nM.

It is important to note that TruRise KetoSurge Fuel with BHB is not for people with Type 1 diabetes or anyone experiencing insulin deficiency, pregnant, breastfeeding, kidney problems, or taking prescribed medications. As always, please consult your healthcare provider before taking any dietary supplements.

18. WHAT IS KETO-ADAPTATION?

Keto-adaptation is a state that is achieved through a significant reduction of carbohydrate intake where the body changes from relying on glycogen as its main source of energy – to relying on fats. Specifically, the brain shifts from being primarily dependent on glucose to being primarily dependent on beta-hydroxybutyrate. This has nothing to do with what a diabetic patient is experiencing in a state of ketoacidosis.

19. SHOULD I MEASURE MY KETONES?

Depending on your goals, you may not care. If you are on a low-carb diet and getting the benefits you hoped for, worrying about how high your ketones are may just add a level of complication you don’t need. On the other hand, many people have found that monitoring their ketones, at least for a while, provides valuable information.

20. HOW TO MEASURE YOUR KETONES:

Measuring blood ketones is the most reliable method. You can also measure ketones in the urine with a test strip, which is much more accessible and inexpensive. However, this method is much less reliable, and as time goes on and the body adapts to ketosis, it becomes even less reliable.

Keto Test Strips

Here are few tips to follow when you use a test strip:
• Pay attention to the expiration date on the strip;
• Be sure to store your test strips with the lid tightly closed.
Any moisture or long exposure to air will cause the strips to not work correctly.

We encourage you to spend some time to do your own research about the many health benefits of the TruRise Low Carbohydrate Lifestyle with Exogenous Ketone Products so you can make the best decision about your health and nutrition. We strongly recommend that you consult your healthcare provider before you start any diet or exercise program.





 

CHECK OUT OUR PRODUCTS ABOVE OR KEEP READING TO FIND OUT THE AMAZING BENEFITS OF OUR EXOGENOUS KETONES



 

WHAT QUESTIONS DO YOU HAVE ABOUT EXOGENOUS KETONES THAT HAVEN’T BEEN ANSWERED?

 

THESE ARTICLES AND LINKS BELOW WILL BETTER HELP TO PROVIDE YOU WITH SOME VERY USEFUL INFORMATION:

 

1) The Charlie Foundation for Ketogenic Therapies:
http://www.charliefoundation.org/

2) Ellen Davis’ Ketogenic Diet Resource:
http://www.ketogenic-diet-resource.com/

3) The Effects of Beta-Hydroxybutyrate on Cognition:
http://www.ncbi.nlm.nih.gov/pubmed/15123336

4) Dietary ketosis enhances memory in mild cognitive impairment:
http://www.ncbi.nlm.nih.gov/pubmed/21130529/

5) Acute nutritional ketosis: implications for exercise performance and metabolism.
Extreme Physiology & Medicine, 3, 17 (Cox, P. J., & Clarke, K. - 2014)
http://doi.org/10.1186/2046-7648-3-17

6) Increased plasma ketone bodies resulted in a corresponding reduction in cerebral metabolic rates of glucose:
http://bit.ly/2mihtWQ

7) Under conditions of ketosis, glucose consumption is decreased in the cortex and cerebellum:
http://bit.ly/2mBi1b8

8) Brain, Livin’ On Ketones – A Molecular Neuroscience Look At The Ketogenic Diet:
http://bit.ly/2n1Ubml

9) Neuroprotective and disease-modifying effects of the ketogenic diet:
http://bit.ly/1Vbzh1q

10) Nutrition and Traumatic Brain Injury: Improving Acute and Subacute Health Outcomes in Military Personnel (2011):
http://www.nap.edu/openbook.php?record_id=13121&page=140

11) Clinical review: Ketones and brain injury:
http://ccforum.biomedcentral.com/articles/10.1186/cc10020

12) No impaired endurance performance when in ketosis:
http://bit.ly/2lYNMaQ

13) Treatment of diabetes and diabetic complications with a ketogenic diet:
http://bit.ly/18fbnJn

14) Insulin Sensitivity and Glucose Tolerance Are Altered by Maintenance on a Ketogenic Diet:
http://bit.ly/2meZ6QW

15) Long-term ketogenic diet reduces blood glucose:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/

16) Ketogenic Diet Could Delay the Effects of Aging:
http://bit.ly/2lYGHXx

17) Scientists see a Ketogenic Diet for Aging and Longevity:
http://bit.ly/2n1NkJP

18) ketosis cleans our cells:
http://bit.ly/2lYHHeu

19) Long-term ketogenic diet significantly reduced the body weight and body mass index of the patients:
http://bit.ly/1vrOVWT

20) Cancer Cells Can’t Live Using Ketones As A Fuel:
http://bit.ly/2mTapRW

21) Ketogenic Diet:
http://articles.mercola.com/sites/articles/archive/2013/03/10/ketogenic-diet.aspx

22) Ketogenic Diet for Cancer – Clinical Trial:
http://bit.ly/2naDvZg

23) Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports:
http://www.ncbi.nlm.nih.gov/pubmed/7790697

MORE GREAT RESEARCH FOR YOU

In case your brain isn’t full yet, here are a few additional studies and resources you may enjoy:

 

1) I.F. Gaunt, M. Sharratt, J. Colley*, A.B.G. Lansdown, P. Grasso (1970). Acute and short-term toxicity of p-hydroxybenzyl acetone in rats. Food and Cosmetics Toxicology, 8(4), 349-358.

2) Clark, V. L., & Kruse, J. A. (1990). Clinical methods: the history, physical, and laboratory examinations. JAMA, 264(21), 2808-2809.

3) Shannon L. Kesl,corresponding author Angela M. Poff, Nathan P. Ward, Tina N. Fiorelli, Csilla Ari, Ashley J. Van Putten, Jacob W. Sherwood, Patrick Arnold, and Dominic P. D’Agostino (2016). Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague–Dawley rats. Nutrition & Metabolism, 13(9).

4) Yeh, Y. Y., & Sheehan, P. M. (1985, April). Preferential utilization of ketone bodies in the brain and lung of newborn rats. In Federation proceedings (Vol. 44, No. 7, pp. 2352-2358).

5) Poff, A. M., Ari, C., Arnold, P., Seyfried, T. N., & D’Agostino, D. P. (2014). Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer. International journal of cancer, 135(7), 1711-1720.

6) Hashim, S. A., & VanItallie, T. B. (2014). Ketone body therapy: from the ketogenic diet to the oral administration of ketone ester. Journal of lipid research, 55(9), 1818-1826.

7) Hertz, L., Chen, Y., & Waagepetersen, H. S. (2015). Effects of ketone bodies in Alzheimer’s disease in relation to neural hypometabolism, β amyloid toxicity, and astrocyte function. Journal of neurochemistry, 134(1), 7-20.

8) Youm, Y. H., Nguyen, K. Y., Grant, R. W., Goldberg, E. L., Bodogai, M., Kim, D., … & Kang, S. (2015). The ketone metabolite [beta]-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nature medicine, 21(3), 263-269.

9) Hall KD, Chen KY, et al. Energy expedition and body composition changes after an isocaloric ketogenic diet in overweight and obese men. Am J Clin Nutr. 2016; 104(2): 324-33

10) Peter Attia, M.D., Nutrition & Health, www.eatingacademy.com, Dec. 2, 2014. There is a limited group of individuals we highly recommend that you follow. This will better help you to keep as up-to-date as possible with all of the current findings on exogenous ketones.

11) Clark K, Tachabanenko K, et al. Kinetics, safety and tolerability of (R)-3-hydroxybutyl ®-3-hydroxybutyrate in healthy adult subjects. Regul Toxicol Pharmacol. 2012;63 (3): 401-8

12) Balasse EO. Kinetic of ketone body metabolism in fasting humans. Metabolism. 1979; 28 (1): 41-50

13) Puchwicz MA, Smith CL, et al. Dog model of therapeutic ketois induced by oral administration of R,S,-1,3-butanedio diacetoacetate. J Nut Biochem. 2000:11 (5): 281-7

14) Sherwn RS, Hendler RG, et al. Effect of ketone infusion on amino acid and nitrogen metabolism in men. J Clin Invest, 1975;55 (6): 1382-90

15) Andrew J. Murry, Nichols S. Knight, Mark A. Cole, Lowri E. Cochlin, Emma Carter, Kirill Tachabanonko, Tica Pichulik, Melanie K. Gulston, Helen J. Atherton, Marie A. Schroeder, Robert M. J. Deacon, Yoshihiro Kashiwaya, M. Todd King, Robert Pawlosky, J. Nicholas P. Rawlin, Damian J. Tyler, Julia L. Griffin, Jeremy Robertson, Richard L. Veech, and Kieran Clarke. Novel ketone diet enhances physical and cognitive performance. The FASEB Journal Vo;. 30 No. 12, PP:4021-4032, April 2017.

16) Veech, Richard L. “The Therapeutic Implications of Ketone Bides: The Effect of Ketone bodies in Pathological Conditions: Ketosis, Ketogenic Diet, Redox States, Insulin Resistance and Mitochondrial Metabolism.” Prostaglandins Leukot Essent Fatty Acids. Mar. 2004;70 (3): 309-19

17) Clarke, t al. Kinetic, Safety and tolerability of (R )-3-hydroxybutyl ( R) 3-hydroxybutyrate in healthy adult subjects. Regul Toxicol Pharmacol. Aug 2012: 63(3).. doi:10.1016/j.jrtph.2012.04.008

18) HM Dashti, TC Mathew, T Hussein, et al. Long-term effect of a ketogenic diet in obese patients. Exp Clin Cardio 2004;9 (3): 200-205.

19) Stephanie L. Ciarlone, Joseph C. Grieco, Dominic P. A’ Agostine, Edwin J. Weeber. Ketone ester supplementation attenuates seizure activity, and improves behavior and hippocampal synaptic plasticity in an Angelman syndrome mouse model. Neurobiology of Disease 96 (2016) 38-46.

20) Peter J. cox, tom Kirk, Tom Ashmore,…Richard L. Veer, Julian L, Griffin, Kieran Clarke. Nutritional ketosis Alters Fuel Performance and Thereby Endurance Performance in Athletes. Cell Metabolism. Aug. 9, 2016

21) Robert Kirkorian, Marcelle D. Shidler, Krista Dangelo, Sarah C. Couch, Stephen C Benoit, Deborah j. Clegg. Dietary ketosis enhances memory in mild cognitive impairment. NIH Public Access. PMC Feb. 1, 2013.

22) Mark A. Roger, Samuel T. Henderson, Cathy Hale, Brenna Cholerton, Laura D. Baker, G.S. Watson, Karen Hyde, Darla Chapman, Suzanne Craft. Effects of B-hydroxybutyrate on cognition in memory impaired adults. Neurobiology of Aging. Mar. 204 Volume 25, Issue3 Page 311-314

23) Yun-Hee Youm, Kim Y Nguyen, Ran W Grant, Emily L Goldberg, Monica Bodogai, Dongin Kim, Dominic D’ Agostino, Noah Planavsky, Christopher Lupfer, Tirumala D Kanneganti, Seokwon Kang, Tomas L Horvath, Tarek M Fahmy, Peter A Crawford, Arya Biragyn, Emad Alnemri & Vishwa Deep Dixi. The ketone metabolite B-hydroxybutyrate blocks NLPR3 inflammasome-mediated inflammatory disease. Nature Medicine-Nature American, Inc. Feb 16, 2015.

24) Shannon L. Kesl, Angela M. Roff, Nathan P. Ward, Tina N fiorelli, Csilla Ari, Ashley J. Van Putten, Jacob W. Sherwood, Patrick Arnold and Dominic P. D’Agostino. Effect of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague—Dawley rats. Kesl et al. Nutritional & Metabolism (2015) 13:9 DOI 10.1186/s12986-016-0069-y.

25) Jeukendrup AE, Saris WH, Brouns F, Halliday D, Wagenmakers JM. Effects of carbohydrate (CHO) and fatty supplementation of CHO metabolism during prolonged exercise. Metabolism. Jul; 1996, 45(7):915-21.

26) Peter J. Cox, Tom Kirk, Tom Ashmore, Richard L, Veech, Julian L. Griffin, Kieran Clarke (2016). Nutritional Ketosis Alters Fuel Performance and There by Endurance Performance in Athletes. Cell Metabolism 24,1-13 August 9, 2016@2016 Elsevier Inc. Cell Press.

27) Maciej Gasior, Michael A.Rogawski and Adam L. Harman (2006) Neuroprotective and Disease-Modifying effects of the Ketogenic diet. Behav Pharmacol. 2006 Sept: 17(5-6): 431-39. HHS Public Access-Peer Reviewed and accepted.

28) Hoffman, J. R., Ratamess, N. A., Kang, J., Rashti, S. L., & Faigenbaum, A. D. (2009). Effect of betaine supplementation on power performance and fatigue. Journal of the International Society of Sports Nutrition, 6(1), 1-10.

29) Olthof, M. R., van Vliet, T., Boelsma, E., & Verhoef, P. (2003). Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women. The Journal of nutrition, 133(12), 4135-4138.

30) Abdelmalek, M. F., Sanderson, S. O., Angulo, P., Soldevila- Pico, C., Liu, C., Peter, J., … & Lindor, K. D. (2009). Betaine for nonalcoholic fatty liver disease: Results of a randomized placebo-controlled trial. Hepatology, 50(6), 1818-1826.

Disclaimer: Any personal testimonials and opinions relating to TruRise and www.trurise.com are not intended to be medical advice and should not be taken as such. Individual results may vary based on diet and exercise implemented. If you are pregnant, nursing, diabetic, on medication, have a medical condition, or are beginning a weight-control program, consult your physician before using TruRise products or making any other dietary changes.